Marija Fjodorova

The paper shows that 24S,25-epoxysterol, an oxysterol linked to neurodevelopmental disorders, promotes neurogenesis and disrupts GABAergic neuronal subtype composition through the liver X receptor pathway.

The paper uses human iPSC-derived medium spiny neurons to show that 16p11.2 CNVs alter striatal neurogenesis and bias toward direct pathway neurons, linking these changes to neurodevelopmental disorders.

The paper investigates the role of BCL11B in neuronal dysfunction in schizophrenia and Huntington's disease, identifying shared and distinct pathogenic mechanisms in striatal medium spiny neurons and cortical neurons.