Ngoc‐Nga Vinh

Discrete cytokine signaling networks instruct distinctsynovial pathotypes in inflammatory arthritis

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

Autism-associated oxysterol regulates GABAergic neurogenesis and subtype fates

The paper shows that 24S,25-epoxysterol, an oxysterol linked to neurodevelopmental disorders, promotes neurogenesis and disrupts GABAergic neuronal subtype composition through the liver X receptor pathway.

Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analyses

The paper uses human iPSC-derived medium spiny neurons to show that 16p11.2 CNVs alter striatal neurogenesis and bias toward direct pathway neurons, linking these changes to neurodevelopmental disorders.

Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia

The paper investigates genetic risk for schizophrenia by analyzing gene expression and regulatory elements in developing ganglionic eminence neurons.