Internal in-frame translation generates Cas11b, which is important for effective interference in an archaeal CRISPR-Cas system
A.-L. Sailer, J. Brendel, Aleksandar Chernev, S. König, Thorsten Bischler, Tom Gräfenhan, Henning Urlaub, Uri Gophna, Anita Marchfelder
The paper identifies Cas11b as an internally translated protein in an archaeal CRISPR-Cas system, showing its necessity for effective interference and Cascade complex formation.
Frontiers in Microbiology · Feb 26, 2025Peer-reviewedMolecular Biology