Aleksandar Chernev

The paper introduces chemical crosslinking with mass spectrometry and a new search engine, NuXL, to identify nucleic acid-protein crosslinks at amino acid resolution, enhancing structural analysis.

The paper identifies Cas11b as an internally translated protein in an archaeal CRISPR-Cas system, showing its necessity for effective interference and Cascade complex formation.

This study determines the cryo-EM structures of human myoferlin and dysferlin bound to Ca2+ and lipids, revealing how their domain dynamics enable membrane binding and fusion.

The paper determines the cryo-EM structure of the human core TFIIH-XPA-DNA complex, revealing how XPA and XPG switch TFIIH from a transcription factor to a DNA repair factor.