Anita Marchfelder

This study identifies CsmR as a transcriptional regulator linking motility and cell shape in Haloferax volcanii through transcriptomic analysis and functional experiments.

The paper identifies Cas11b as an internally translated protein in an archaeal CRISPR-Cas system, showing its necessity for effective interference and Cascade complex formation.

The paper develops a new expression system for WR806 to study Cas1 in DNA repair, showing improved protein expression control and revealing dose-dependent mobility changes in Cas1 after UV damage.

The paper re-sequences 60 archaeal strains from two species to assess genetic divergence and identify mutations arising from lab manipulations and transfers.

The paper deletes four proviruses in Haloferax volcanii and finds increased motility, stress resistance, and altered CRISPR RNA expression.

The paper identifies a small RNA (s479) in H. volcanii that regulates zinc transport and interacts with CRISPR-Cas components, suggesting a link between CRISPR-Cas and sRNA function.

This study identifies RNA 3' termini and termination sites in Haloferax volcanii using a novel algorithm and RNAseq data, revealing distinct motifs for intergenic and coding regions.