Zeshi Li

SOLiD-MaP maps small molecule binding sites on RNA using photoproximity labeling, demonstrating target-selective labeling and mutational profiling to identify binding regions.

The paper identifies heparan sulfate (HS) as a key factor for cell-surface RNA (csRNA) presentation and reveals a ternary complex of HS, RNA, and RNA-binding proteins that recruits immune receptors.

The paper identifies potential ambiguities in glycoRNA analysis by showing that RNase sensitivity of glycosylated RNA species depends on purification methods, suggesting co-purification of non-glycoRNA glycoconjugates.

The paper describes a chemoenzymatic method to synthesize O-acetylated GD3 gangliosides and uses them to study viral receptor specificities in a cellular context.

This paper identifies 9-O-acetylated sialic acids as a ligand for the SARS-CoV-2 NTD, revealing a dual-receptor functionality in the S1 domain that was rapidly selected against.