Marvin E. Tanenbaum

This paper introduces Waldo, a genetic barcoding system that links live-cell imaging phenotypes to single-cell sequencing data for the same cells.

The paper defines an extended translation initiation sequence (eTIS) and shows that a deep-learning model trained on eTIS features accurately predicts translation initiation, revealing that the Kozak sequence is not optimal and identifying conserved nucleotides that enhance initiation efficiency.

The paper develops a live-cell imaging assay to visualize and quantify extracellular vesicle fusion with target cells, enabling study of spatiotemporal dynamics and molecular regulators of EV fusion.

This study shows that RSV forms condensates by pre-assembling replication centers within viral particles, explaining infection heterogeneity and enabling efficient replication without requiring pre-existing condensates.

This study uses live-cell single-molecule imaging to show that proteasome substrate processing depends on engagement mode, not just substrate identity or folding.

The paper identifies heparan sulfate (HS) as a key factor for cell-surface RNA (csRNA) presentation and reveals a ternary complex of HS, RNA, and RNA-binding proteins that recruits immune receptors.

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

The paper identifies potential ambiguities in glycoRNA analysis by showing that RNase sensitivity of glycosylated RNA species depends on purification methods, suggesting co-purification of non-glycoRNA glycoconjugates.

The paper identifies genome-lamina reorganization preceding long gene activation in mouse corticogenesis and links it to MeCP2 binding.

This study demonstrates that enterovirus 2A protease is critical for viral replication and evasion of host antiviral responses through multiple mechanisms.

This study maps the complete influenza A virus infection cycle in individual cells, identifying key factors driving infection heterogeneity.

This study uses single-ribosome imaging and simulations to show that transient ribosome collisions promote efficient translation by suppressing ribosome pausing and recycling.

This study develops socRNA imaging to track single ribosomes, revealing ribosomal heterogeneity and translation elongation fidelity.

The paper develops a live-cell imaging assay to study how mRNA structures affect AGO2-siRNA interactions and mRNA degradation.