Author

Eva Lepinay

Centre de recherche du CHU de Québec-Université LavalORCID 0000-0002-8385-3433Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Francesca CicchettiiD· 2 shared Abid OueslatiiD· 1 shared Alex RajputiD· 1 shared Alexandra Ricard· 1 shared Anne‐Laure Mahul‐MellieriD· 1 shared Ariele da Silva MartinsiD· 1 shared Christine Insinna· 1 shared Christine Trabolsi· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Francesca CicchettiORCID

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2 papers

Recent·Most cited

Neutrophil Extracellular Traps Mediate In Vitro and In Vivo Degradation of α-Synuclein Amyloid Fibrils

Thyago R. Cardim-Pires, Ariele da Silva Martins, Fernanda Verdini Guimarães, Thayana R. F. Mattos, Eva Lepinay, Martine Saint‐Pierre, Francesca Cicchetti, Elvira M. Saraiva, Patrícia Machado Rodrigues Silva, Débora Foguel

This study shows that neutrophil extracellular traps (NETs) degrade α-synuclein amyloid fibrils in vitro and in vivo, improving lung function by clearing these fibrils from lung tissue.

Journal of Inflammation Research · Sep 1, 2026Peer-reviewedBiochemistry

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease

Maxime Teixeira, Razan Sheta, Morgan Bérard, Christine Insinna, Anne‐Laure Mahul‐Mellier, Constantin V. L. Delmas, Eva Lepinay, Walid Idi, Alexandra Ricard, Esther del Cid‐Pellitero, Christine Trabolsi, Stéphane Gobeil, Marie‐Hélène Canron, Erwan Bézard, Alex Rajput, , Abid Oueslati

This study identifies WDR44 as a driver of de novo α-synuclein aggregation at the lysosomal membrane, linking early aggregation events to neuronal dysfunction in Parkinson's Disease.

bioRxiv · Apr 7, 2026 · PreprintNeuroscience