Francesca Cicchetti

This study shows that neutrophil extracellular traps (NETs) degrade α-synuclein amyloid fibrils in vitro and in vivo, improving lung function by clearing these fibrils from lung tissue.

This study compares how different BBB models affect immune cell trafficking in PD, showing that model architecture significantly influences results.

This study identifies WDR44 as a driver of de novo α-synuclein aggregation at the lysosomal membrane, linking early aggregation events to neuronal dysfunction in Parkinson's Disease.

The paper identifies Anxa1 as a marker for PD-vulnerable dopamine neurons and shows they respond oppositely to excitatory inputs compared to resilient Vglut2+ neurons.

This study identifies vessel-type-specific vascular barrier dysfunction in Huntington's disease and shows partial rescue with an S1PR1 agonist.

The paper demonstrates that CRISPR-Cas9 nickase can contract CAG/CTG repeats in patient-derived cells and improve molecular and behavioral phenotypes in Huntington's disease.