Secreted Particle Information Transfer (SPIT) - A Cellular Platform For In Vivo Genetic Engineering
Carsten T. Charlesworth, Shota Homma, Fabian Patrik Suchy, Sicong Wang, Joydeep Bhadury, Anais K. Amaya, Joab Camarena, Jinyu Zhang, Tze-Kai Tan, Kyomi J. Igarashi, Hiromitsu Nakauchi
The paper introduces SPIT, a method using human cells to deliver genetic tools in vivo, demonstrating its application for modifying multiple organs and tissues in immunocompetent mice.
bioRxiv · Jan 11, 2024 · PreprintSynthetic Biology