Kyomi J. Igarashi

Disentangling cell-intrinsic and extrinsic factors underlying evolution

The paper decomposes evolutionary divergence into cell-intrinsic, extrinsic, and interaction components using reciprocal rat-mouse chimeras and finds cell-intrinsic factors dominate but extrinsic factors also play a role.

Secreted Particle Information Transfer (SPIT) - A Cellular Platform For In Vivo Genetic Engineering

The paper introduces SPIT, a method using human cells to deliver genetic tools in vivo, demonstrating its application for modifying multiple organs and tissues in immunocompetent mice.

In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis

This study uses in vivo CRISPR screening to identify SAGA complex members as key regulators of hematopoiesis, showing their loss impairs blood production and activates interferon pathways.

DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

The paper identifies DNA methylation as a key mechanism for maintaining monoallelic expression on autosomes and reveals its tunable control of allele-specific expression.