Shota Homma

This study identifies xenophagocytosis as an innate immune barrier that limits interspecies chimerism and shows that blocking it enhances donor cell engraftment in mouse embryos.

The paper introduces SPIT, a method using human cells to deliver genetic tools in vivo, demonstrating its application for modifying multiple organs and tissues in immunocompetent mice.

This paper describes a genome editing strategy that restores hemoglobin production in α-thalassemia major-derived hematopoietic stem and progenitor cells by integrating a functional α-globin gene and a truncated erythropoietin receptor.