Fabian Patrik Suchy

TorPause is a two-component preservation method that reduces ischemia-reperfusion injury in rat liver transplants by pausing metabolism and protecting mitochondria.

This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.

This study identifies xenophagocytosis as an innate immune barrier that limits interspecies chimerism and shows that blocking it enhances donor cell engraftment in mouse embryos.

This study shows DNMT3AR882H mutations are not required for maintaining AML but are linked to higher leukemia stem cell frequency.

This study transplants human iPSC-derived pancreatic progenitors into Pdx1-deficient mice, extending their lifespan and demonstrating functional engraftment of human pancreatic cells.

The paper introduces SPIT, a method using human cells to deliver genetic tools in vivo, demonstrating its application for modifying multiple organs and tissues in immunocompetent mice.

This paper develops a droplet digital PCR assay to quantify chimerism in mouse tissues, showing it is robust, minimally biased, and compatible with crude lysates.

This paper demonstrates that chimpanzee iPSCs can form cross-species chimeras with rhesus macaque embryos, suggesting functional similarity between human and chimpanzee cells.