Author

Dina Coertzen

University of PretoriaORCID 0000-0002-8408-244XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Arne AlderiD· 1 shared Charisse Flerida A. PasajeiD· 1 shared Christian ScheureriD· 1 shared Dale TayloriD· 1 shared David A. FidockiD· 1 shared Elizabeth A. WinzeleriD· 1 shared Francisco‐Javier GamoiD· 1 shared Gareth GirlingiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Arne AlderORCID

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1 paper

Recent·Most cited

MicrobiologyACS Chemical BiologyPeer-reviewedJun 13, 2026

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie…·Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

5 citationstop 1%

humanmouse

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