Author

Larnelle F. Garnie

University of Cape TownORCID 0000-0002-3993-0665Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

Kathryn J. WichtiD· 2 shared Arne AlderiD· 1 shared Charisse Flerida A. PasajeiD· 1 shared Christian ScheureriD· 1 shared Dale TayloriD· 1 shared David A. FidockiD· 1 shared Dina CoertzeniD· 1 shared Elizabeth A. WinzeleriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Kathryn J. WichtORCID

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2 papers

Recent·Most cited

MicrobiologyACS Chemical BiologyPeer-reviewedJun 13, 2026

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie…·Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

5 citationstop 1%

humanmouse

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Molecular BiologyCommunications BiologyPeer-reviewedNov 13, 2025

Heme Detoxification in the Malaria Parasite Plasmodium falciparum: A Time-Dependent Basal-Level Analysis

Larnelle F. Garnie, Timothy J. Egan, Kathryn J. Wicht

This study analyzes the time-dependent changes in the digestive vacuole of Plasmodium falciparum parasites, identifying three developmental phases and differences between CQ-sensitive and CQ-resistant strains.

6 citationstop 4%

plant (other)experimental assay

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