Author

John G. Woodland

South African Medical Research CouncilORCID 0000-0001-6273-5596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Kelly ChibaleiD· 2 shared Ankur KumariD· 1 shared Arne AlderiD· 1 shared Charisse Flerida A. PasajeiD· 1 shared Christian ScheureriD· 1 shared Dale TayloriD· 1 shared David A. FidockiD· 1 shared Dina CoertzeniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

Kelly ChibaleORCID

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2 papers

Recent·Most cited

MicrobiologyACS Chemical BiologyPeer-reviewedJun 13, 2026

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie…·Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

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humanmouse

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BioinformaticsNature CommunicationsPeer-reviewedSep 15, 2023

First fully-automated AI/ML virtual screening cascade implemented at a drug discovery centre in Africa

Gemma Turón, Jason Hlozek, John G. Woodland…·Miquel Duran‐Frigola

ZairaChem, an AI/ML tool, increases hit rates in drug discovery by 40% through automated virtual screening at a low-resource African research center.

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machine learning (classical)drug response / drug discovery

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