Author

Kelly Chibale

South African Medical Research CouncilORCID 0000-0002-1327-4727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Charisse Flerida A. PasajeiD· 2 shared Elizabeth A. WinzeleriD· 2 shared Henrico LangeveldiD· 2 shared Jacquin C. NilesiD· 2 shared John G. WoodlandiD· 2 shared Kathryn J. WichtiD· 2 shared Lauren B. CoulsoniD· 2 shared Luiz Claudio GodoyiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Charisse Flerida A. PasajeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologyACS Chemical BiologyPeer-reviewedJun 13, 2026

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie…·Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

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humanmouse

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Molecular BiologyAngewandte Chemie International EditionPeer-reviewedOct 23, 2025

Targeting Aurora kinases as essential cell cycle regulators to deliver multi-stage antimalarials against Plasmodium falciparum

Henrico Langeveld, Keletso Maepa, Marché Maree…·Lyn‐Marié Birkholtz

The paper identifies PfArk1 as a key target for antimalarial drugs by showing that inhibiting it disrupts parasite mitosis and nuclear division.

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experimental assaydrug response / drug discovery

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BioinformaticsNature CommunicationsPeer-reviewedSep 15, 2023

First fully-automated AI/ML virtual screening cascade implemented at a drug discovery centre in Africa

Gemma Turón, Jason Hlozek, John G. Woodland…·Miquel Duran‐Frigola

ZairaChem, an AI/ML tool, increases hit rates in drug discovery by 40% through automated virtual screening at a low-resource African research center.

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machine learning (classical)drug response / drug discovery

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