Karin R. Sipido

The paper identifies MGST1 as a key antioxidant gene in cardiac fibroblasts, showing its loss in heart failure increases oxidative stress and ferroptosis susceptibility.

This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.

This study uses DMD patient iPSCs to model cardiomyopathy, identifies NOX4 as a therapeutic target due to its role in ROS production, and shows interventions that reduce oxidative stress and improve cell survival.

The paper shows that MSK-mediated phosphorylation of histone H3 at serine 28 couples MAPK signaling with chromatin remodelling and immediate early gene expression to induce pro-hypertrophic cardiac transcriptional responses.