Author

James Han Lai

Harvard UniversityORCID 0000-0002-8414-0398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:imaging· 1

Frequent Co-Authors

Cenk AyataiD· 2 shared David Y. ChungiD· 2 shared Elyssa Alber· 2 shared Lydia Hawley· 2 shared Muhammed Miran ÖnceliD· 2 shared Sava SakadžićiD· 2 shared A. Richard Thompson· 1 shared Aarushi Gandhi· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPhysiology

Cenk AyataORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintJan 26, 2026

Smooth Muscle Dysfunction Drives Cerebrovascular Reserve Failure and End-Organ Brain Injury

Takahiko Imai, Vijai Krishnan, James Han Lai…·David Y. Chung

This study shows that smooth muscle dysfunction caused by ACTA2 mutations leads to cerebrovascular reserve failure, increasing brain vulnerability to hypoperfusion and injury.

DOI 10.64898/2026.01.26.701890

mouseimaging

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NeurosciencebioRxivPreprintSep 17, 2025

Olfactory Bulb Pinprick Induction of Cortical Spreading Depolarizations

Muhammed Miran Öncel, Michael Dora, Lydia Hawley…·David Y. Chung

This study introduces a non-invasive method to induce cortical spreading depolarizations in rodents using olfactory bulb pinprick, showing reliable CSD induction without cortical injury.

DOI 10.1101/2025.09.17.671112

mouseexperimental assay

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