Sava Sakadžić

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

This study shows that smooth muscle dysfunction caused by ACTA2 mutations leads to cerebrovascular reserve failure, increasing brain vulnerability to hypoperfusion and injury.

This paper develops a biophysical model to simulate fMRI responses in mice and humans, revealing species-specific hemodynamic differences and conserved vascular asymmetries.

This study introduces a non-invasive method to induce cortical spreading depolarizations in rodents using olfactory bulb pinprick, showing reliable CSD induction without cortical injury.

This study investigates how global hypoperfusion affects oxygen delivery and consumption in the cerebral watershed area compared to the MCA territory using in vivo imaging techniques in mice.

The paper introduces a shallow-angle cannula for repeated drug delivery and in vivo imaging in mice, demonstrating its use for tracking degenerating neurons and measuring brain oxygen levels.

This study shows carbonic anhydrase inhibitors prevent capillary flow issues in a mouse model of early Alzheimer's disease before symptoms appear.

The paper shows that hemodynamic responses in the cortex are influenced by neuromodulators like norepinephrine, with distinct impulse response functions for different neuromodulatory signals.

The paper describes a widefield in vivo imaging system for mesoscopic brain imaging, capable of capturing fluorescent and reflectance signals, and demonstrates its use in awake mice.

This study shows aerobic exercise improves microvascular perfusion and oxygenation in deep brain regions of aged mice, correlating with better cognitive function.

The paper identifies residual neural crest stem cells in adult mouse meninges that are reactivated for vascular repair after injury.

The paper measures oxygen consumption across cortical layers in awake mice and finds a decrease in baseline CMRO2 from layer I to IV, accompanied by increased tissue oxygenation.

This paper develops a deep learning method for segmenting brain vasculature from two-photon microscopy images, achieving faster computation and better generalization across imaging systems.

This study shows that subarachnoid hemorrhage in mice causes early and lasting changes in functional connectivity and cognitive performance.

The paper introduces a new method to estimate spatially resolved CMRO2 from pO2 measurements using the Laplace method, balancing noise reduction and bias.

The paper identifies dynamic capillary flow stalls in mice after stroke reperfusion, mediated by neutrophils, which impair circulation and contribute to penumbral injury.

The paper measures capillary flow and oxygenation in cortical layers of awake mice, finding homogenization of oxygen delivery and increased extraction in layer IV.