PITX2C Deficiency Promotes Arrhythmogenic Remodeling via Oxidative Stress in Atrial Myocytes
Andy Kim, Sébastien Gauvrit, Frederick S Vizeacoumar, Michelle M. Collins
This study shows that PITX2C deficiency leads to reduced oxidative metabolism and increased oxidative stress in atrial myocytes, causing arrhythmogenic remodeling and structural changes, which can be mitigated by antioxidants.