Dian Yang

This study uses spatial transcriptomics and lineage tracing to show how tumor subclones drive microenvironmental changes that promote metastasis in a mouse model.

PEtracer maps cell state and lineage dynamics in vivo with high spatial resolution using prime editing and multimodal imaging.

This study identifies CD47 as a more effective macrophage immune checkpoint than CD24 in cancer and develops bispecific antibodies to enhance macrophage-mediated tumor killing.

The paper introduces dynamo, a framework for estimating RNA velocities and predicting cell fates using single-cell RNA-seq data, applied to various biological processes.

The paper introduces Repair-seq to study DSB repair by profiling genetic perturbations and identifies dependencies and novel mechanisms in repair pathways.

The paper develops a molecular recorder to track lineage and define a mouse cell fate map using scRNA-seq, revealing transcriptional convergence of endodermal cells and estimating progenitor cell numbers.