Ling Jia

This study identifies SUGP1 as a key splicing factor in piRNA biogenesis in Bombyx mori, revealing its interaction with Y-box protein and dual role in piRNA maturation and transposon regulation.

The paper develops a CRISPR-based method to generate a large-scale mutant library in Bombyx mori, identifying genes involved in phenotypic changes and environmental tolerance.

The paper maps the genetic interaction network of PARP inhibitor response by analyzing 147,153 pairwise interactions and reveals hierarchical pathway organization and context-specific buffering interactions.

The paper introduces Repair-seq to study DSB repair by profiling genetic perturbations and identifies dependencies and novel mechanisms in repair pathways.

The paper identifies three classes of enhancers regulated by Bicoid and Orthodenticle in Drosophila embryos, revealing a feed-forward relay mechanism that coordinates gene expression timing.