Stefanie Grosswendt

This study shows that SRRM2 splicing factor dosage affects embryonic stem cell pluripotency and lineage commitment, with implications for developmental diseases and tumorigenesis.

The paper develops a molecular recorder to track lineage and define a mouse cell fate map using scRNA-seq, revealing transcriptional convergence of endodermal cells and estimating progenitor cell numbers.

This paper introduces a method for fixing and preserving cells for single-cell transcriptomics, demonstrating its effectiveness across species and tissue types.