Xia Wang

The paper investigates cohesin-mediated chromatin loop extrusion in human cells, revealing two dynamic modes of extrusion and showing that CTCF depletion increases extrusion activity.

This study evaluates the comparability of cell-free DNA measurements using digital PCR across 12 laboratories, showing high technical accuracy for variant copy number and allele frequency.

The paper introduces RNA reference materials and ratio-based datasets to improve the reliability and benchmarking of transcriptomic profiling.

This paper introduces a somatic genetics approach using AAV-based expression and knockout to study sleep in adult mice, identifying new sleep regulators and demonstrating its utility for essential or redundant genes.