SETD5 dysfunction in human astrocytes drives IL-6-mediated neuronal impairments via the JAK/STAT signaling pathway
Angels Almenar‐Queralt, Isabella Rodrigues Fernandes, Janaina S de Souza…·Alysson Renato Muotri
This study shows that SETD5 dysfunction in astrocytes increases IL-6, which harms neurons via JAK/STAT signaling, suggesting therapeutic targeting of this pathway for ASD and ID.