Author

Ah Young Lee

Ludwig Cancer ResearchORCID 0000-0002-3489-7798Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:gene regulatory network inference· 6 Research Focus:differential expression· 5 Assay:DNA methylation· 5 Approach:statistical model· 5 Assay:ChIP-seq· 4 Approach:experimental assay· 4 Organism:mouse· 4 Organism:human· 3

Frequent Co-Authors

Bing ReniD· 4 shared Hui HuangiD· 3 shared Rongxin FangiD· 3 shared Sebastian PreißliD· 3 shared Yunjiang QiuiD· 3 shared Axel ViseliD· 2 shared Bin LiiD· 2 shared Brian A. WilliamsiD· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Bing RenORCID

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6 papers

Recent·Most cited

Epigenomic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potentials

C.-C. Cheng, Ming Fung Cheung, Ah Young Lee, Qiong Wu, Savio Ho-Chit Chow, Julie Ying Jin Ang, Ignacio Riquelme Medina, Grace Lo, Haoran Wu, Weiqin Yang, Paul B.S. Lai, Kevin Yuk-Lap Yip, Alfred S.L. Cheng, Danny Leung

This study identifies epigenetic changes in HCC that affect cis-regulatory elements and retrotransposons, linking them to gene dysregulation and poor prognosis.

bioRxiv · Sep 16, 2024 · PreprintGenomics

Identification of Evolutionarily Conserved VSX2 Enhancers in Retinal Development

Victoria Honnell, Shannon Sweeney, Jacqueline L. Norrie, Cody Ramirez, Beisi Xu, Brett J.W. Teubner, Ah Young Lee, Claire M. Bell, Michael A. Dyer

The paper identifies evolutionarily conserved VSX2 enhancer modules in retinal development and shows their functional conservation across species.

bioRxiv · Oct 17, 2023 · PreprintDevelopmental Biology

Spatiotemporal DNA Methylome Dynamics of the Developing Mammalian Fetus

Yupeng He, Manoj Hariharan, David U. Gorkin, Diane E. Dickel, Chongyuan Luo, Rosa Castanon, Joseph R. Nery, Ah Young Lee, Yuan Zhao, Hui Huang, Brian A. Williams, Diane E. Trout, Henry Amrhein, Rongxin Fang, Huaming Chen, , Joseph R. Ecker

The paper maps DNA methylation changes across 12 mouse tissues at 8 developmental stages, identifying methylation variant regions and tissue-specific enhancers linked to human genetic diseases.

Nature · Jul 29, 2020Peer-reviewedGenomics

Systematic mapping of chromatin state landscapes during mouse development

David U. Gorkin, Iros Barozzi, Yuan Zhao, Yanxiao Zhang, Hui Huang, Ah Young Lee, Bin Li, Joshua Chiou, André Wildberg, Bo Ding, Bo Zhang, Mengchi Wang, J. Seth Strattan, Jean M. Davidson, Yunjiang Qiu, , Bing Ren

The paper systematically maps chromatin state landscapes during mouse development by profiling histone modifications across 72 tissue-stages, identifying dynamic enhancers and transcriptional regulators.

Nature · Jul 29, 2020Peer-reviewedGenomics

3D Chromatin Architecture Remodeling during Human Cardiomyocyte Differentiation Reveals A Role Of HERV-H In Demarcating Chromatin Domains

Yanxiao Zhang, Ting Li, Sebastian Preißl, Maria Luisa Amaral, Jonathan D. Grinstein, Elie N. Farah, Eugin Destici, Yunjiang Qiu, Rong Hu, Ah Young Lee, Sora Chee, Kaiyue Ma, Zhen Ye, Quan Zhu, Hui Huang, , Bing Ren

The paper investigates chromatin architecture changes during human cardiomyocyte differentiation and identifies HERV-H retrotransposons as key regulators of TAD boundaries and gene regulation.

Nature Genetics · Aug 19, 2019Peer-reviewedGenomics

Histone H3 Lysine 4 methyltransferases MLL3 and MLL4 Modulate Long-range Chromatin Interactions at Enhancers

Jian Yan, Shi-An A. Chen, Andrea Local, Tristin Liu, Yunjiang Qiu, Ah Young Lee, Inkyung Jung, Sebastian Preißl, Chloe M. Rivera, Chaochen Wang, Haruhiko Ishii, Rongxin Fang, Zhen Ye, Kai Ge, Ming Hu, Bing Ren

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.

bioRxiv · Feb 21, 2017 · PreprintGenomics