C. Neil

MERFISH+ enables high-resolution spatial multi-omics mapping of gene expression and chromatin organization in developing human hearts with subcellular resolution.

The paper integrates single-cell multi-omics and 3D genome data from human hearts to identify gene regulatory changes and causal genetic contributors in heart failure.

The paper shows that zebrafish require both ancestral and derived Ankfn1 paralogs for vestibular function, with partial redundancy.

The paper reveals unexpected complexity and multipotentiality of early heart fields through lineage and single-cell analyses, identifying new progenitor sources and developmental relationships.

The paper defines cardiac cell type-specific cis-regulatory elements and links disease risk variants to these elements in human hearts.

This study identifies one known and two novel genetic variants associated with heart failure through GWAS and multi-omic analyses, revealing potential causal mechanisms and shared heritability with musculoskeletal traits.

The paper investigates chromatin architecture changes during human cardiomyocyte differentiation and identifies HERV-H retrotransposons as key regulators of TAD boundaries and gene regulation.