Pierre Vincent

Cross-pathway integration of cAMP signals through cGMP and calcium-regulated phosphodiesterases in mouse striatal cholinergic interneurons.

The paper investigates cAMP signaling dynamics in mouse striatal cholinergic interneurons, revealing distinct regulatory mechanisms involving phosphodiesterases and neuromodulators like NO and glutamate.

Pivotal role of PDE10A in the integration of dopamine signals in mice striatal D1 and D2 medium-sized spiny neurones.

The paper investigates the role of PDE10A in dopamine signal integration in striatal D1 and D2 MSNs using FRET biosensors, finding that PDE10A uniquely reduces cAMP to baseline in both neuron types.

Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration

The paper shows that primary cilia regulate neuronal migration through cAMP/PKA signaling at the centrosome, with genetic and imaging experiments demonstrating the role of ciliary Adenylate Cyclase 3 and centrosomal PKA.

Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals

The paper investigates ERK activation in the tail of the striatum (TS) in response to various stimuli, finding that D1R-SPNs in specific subterritories are activated by psychostimulants but not hallucinogens.