Emmanuel Valjent

This study uses active place avoidance and machine learning to show that defensive behaviors in mice depend on threat imminence, punishment intensity, and behavioral agency, with sex-dependent differences.

This study identifies PAI-1 as a blood biomarker and brain risk factor for PTSD, showing increased levels in PTSD-like models and soldiers with PTSD symptoms.

This study shows that daily intermittent fasting reduces seizure frequency and improves sociability in mouse models of absence epilepsy without adverse effects.

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

This study uses mouse models to investigate the role of Gnal loss in specific striatal projection neurons, revealing distinct effects on motor behavior and drug responses.

The paper profiles the translatome of dorsal striatum PV interneurons, identifying molecular signatures and gene expression changes linked to psychostimulant exposure and reward behaviors.

This study investigates the role of dopamine D2 autoreceptors in regulating VTA dopamine neuron responses to aversive stimuli and finds they act as a regulatory brake with sex-biased effects on threat processing.

This study shows that dopamine D1 receptor activation in the anterior insula increases anxiety-related behaviors and disrupts neural coding of exposed versus protected spaces.

This study investigates the sex-specific effects of NALCN deletion in Drd2-expressing striatal spiny projection neurons, revealing sex differences in excitability and behavior.

The paper shows nicotine inhibits amygdala-projecting dopamine neurons via a VTA-NAc feedback loop, leading to anxiety.

The paper identifies ADGRL1 and hevin as genetic risk factors for psychiatric disorders and substance abuse by showing their functional interaction in reward mechanisms in the nucleus accumbens.

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

The paper characterizes NMU-expressing neurons in the adult mouse brain using a Nmu-Cre knock-in model, revealing a midline modulatory circuit centered on the VMH.

This study shows that dopamine D2 receptors modulate hippocampal theta rhythms via somatostatin interneurons by altering their excitability through distinct intracellular pathways.

The paper investigates how haloperidol induces immediate early genes in striatopallidal neurons through the combined action of cAMP/PKA/DARPP-32 and mTOR pathways.

The paper compares intrinsic properties of D1- and D2-MSNs in FXS mice and finds they lose their distinct characteristics, leading to a uniform phenotype.

The paper identifies a circuit mechanism involving SST+ vlPAG cells projecting to the RVM that regulate analgesia during defensive states in mice.

This study shows that dopamine D2 receptors in the extended amygdala are crucial for switching between passive and active defensive behaviors in response to threats.

This paper shows that d-amphetamine and methylphenidate increase GluA1 phosphorylation at Ser845 in mouse cerebellar Bergmann Glia Cells via norepinephrine signaling.

The paper identifies translational and splicing differences in dopaminoceptive neurons and highlights PGE2's role in enhancing D2 dopamine receptor function in the dorsal striatum.

This study shows that mTOR-RhoA signaling in direct striatal projection neurons affects behavior and striatal physiology in mice, with implications for treating mTOR-related disorders.

This study shows that dopamine D2 receptors in parvalbumin interneurons of the mouse primary motor cortex increase neuronal excitability and GABAergic synaptic transmission to pyramidal neurons.

This study shows that cerebellar dopamine D2 receptors in Purkinje cells regulate social novelty preference in mice without affecting motor functions.

The paper examines synaptic connectivity and plasticity in the adult mouse nucleus accumbens core, revealing pathway- and cell-type specific contributions of BLA, PFC, and vHipp inputs, and the role of endocannabinoid receptors.

The paper investigates ERK activation in the tail of the striatum (TS) in response to various stimuli, finding that D1R-SPNs in specific subterritories are activated by psychostimulants but not hallucinogens.

This paper introduces hybrid cell-free biosensors that expand the range of detectable chemicals by combining synthetic metabolic cascades with transcription factor-based networks.