Alain Trembleau

GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration

The paper shows that GPR161 at the primary cilium senses mechanical stimuli to drive cyclic saltatory neuronal migration through cAMP/PKA signaling and NDE1 phosphorylation.

Laminin gamma1-dependent basement membranes are instrumental to ensure proper olfactory placode shape, position and boundary with the brain, as well as olfactory axon development

This study investigates the role of Laminin gamma1-dependent basement membranes in olfactory placode development and axon guidance in zebrafish.

FMRP regulates tangential neuronal migration via MAP1B

This study shows that FMRP regulates neuronal migration by controlling MAP1B, which affects microtubule structure during migration in Fmr1-null mice.

Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements

This study shows that loss of floor plate Netrin-1 disrupts corticospinal tract midline crossing in mice, causing mirror movements similar to human congenital conditions.

Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration

The paper shows that primary cilia regulate neuronal migration through cAMP/PKA signaling at the centrosome, with genetic and imaging experiments demonstrating the role of ciliary Adenylate Cyclase 3 and centrosomal PKA.