Store-operated Ca2+ entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells
Aleksandra Babicheva, Ibrahim Shehata Elmadbouh, Shanshan Song, Michael A Thompson, Ryan Powers, Pritesh Jain, Amin Izadi, Jiyuan Chen, Lauren Yung, Sophia Parmisano, Cole Paquin, Wei‐Ting Wang, Yuqin Chen, Ting Wang, Mona Alotaibi, , Jason X.‐J. Yuan
This study shows that TGF-β1-induced endothelial-to-mesenchymal transition in human lung vascular endothelial cells is Ca²⁺-dependent through store-operated Ca²⁺ entry via STIM1/Orai1 channels.
American Journal of Physiology-Lung Cellular and Molecular Physiology · May 7, 2025Peer-reviewedCell Biology