Christina M. Pabelick

Mechanosensitive Piezo Channels Contribute to Airway Changes in Chronic Obstructive Pulmonary Disease

This study investigates the role of Piezo1/2 channels in airway smooth muscle cells of COPD patients, finding altered expression and function linked to ECM changes.

Loss of miRNA-153 promotes endothelial-to-mesenchymal transition and compromises lung vascular integrity

This study shows that loss of miR-153 promotes EndMT in lung endothelial cells, leading to vascular permeability and remodeling in pulmonary hypertension.

Store-operated Ca2+ entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells

This study shows that TGF-β1-induced endothelial-to-mesenchymal transition in human lung vascular endothelial cells is Ca²⁺-dependent through store-operated Ca²⁺ entry via STIM1/Orai1 channels.