Matthew R. King

Condenzymes: Biomolecular condensates with inherent catalytic activities

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

Molecular grammars of intrinsically disordered regions that span the human proteome

The paper introduces GIN, a resource that decodes molecular grammars of human intrinsically disordered regions (IDRs) and identifies their functional roles in biological processes and disease.

Synapsin condensation is governed by sequence-encoded molecular grammars

This study identifies sequence-encoded molecular grammars in synapsin-1 IDRs that drive condensation and generate pH gradients relevant for synaptic function.