Author

Xiao Guo

Sichuan UniversityPrimary ORCID profile (0000-0002-0533-3547 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Xiao GuoiD1 paper · University of California, Los Angeles

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Anton Z. NiiD· 1 shared Hongyun Wang· 1 shared J Liu· 1 shared Jiejie LiuiD· 1 shared Jikai DengiD· 1 shared Joonho LeeiD· 1 shared Ke LaniD· 1 shared Leshan Yang· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Anton Z. NiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Condenzymes: Biomolecular condensates with inherent catalytic activities

Michael W. Chen, Xiao Guo, Mina Farag, Naixin Qian, Xiaowei Song, Anton Z. Ni, Vicky Liu, Yu Xia, Yuefeng Ma, Leshan Yang, Wen Yu, Matthew R. King, Joonho Lee, Richard N. Zare, Wei Min, , Yifan Dai

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

Molecular Cell · Jul 24, 2026Peer-reviewedBiophysics

Poly(A)-tail-length-dependent surveillance of viral RNA by PABPC1 orchestrates broad-spectrum antiviral defense

Shimin Yang, Li Zhou, Xiaoya Huang, Shunhua Zhu, Weiyi Yu, Xiao Guo, J Liu, Jikai Deng, Yuzhen Zhang, Jiejie Liu, Qianyun Liu, Ming Guo, Wenjie Xiang, Xin Wang, Zhen Zhang, , Yu Chen

This study identifies PABPC1 as a host factor that selectively targets viral RNA with short poly(A) tails, leading to degradation and antiviral defense, and develops a synthetic therapeutic based on this mechanism.

bioRxiv · Jan 13, 2026 · PreprintMicrobiology