Hye‐Soon Lee

Fine-mapping SLE-MHC associations revealed independent contributions of HLA missense variants and C4 copy number variations

This study identifies independent genetic contributions of HLA missense variants and C4 copy number variations to SLE risk using a new East Asian MHC imputation panel.

Cell-type-specific transcriptome architecture underlying the establishment and exacerbation of systemic lupus erythematosus

This study identifies cell-type-specific transcriptomic signatures associated with SLE disease establishment and exacerbation, highlighting their clinical relevance and potential limitations in capturing genetic risk factors.

Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

This study conducts a trans-ancestry GWAS of rheumatoid arthritis, identifying 124 loci, 34 novel, and shows improved polygenic risk score performance across populations.

Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

This study identifies 113 genomic loci for SLE in East Asians, including 46 novel loci, and highlights non-immune cell-related biological mechanisms.