Yusuke Takeshima

The paper introduces a framework for multimodal chemical screens combining RNA, protein, and epigenomic readouts, revealing compound-specific mechanisms and off-target effects in T cells.

This paper introduces icCITE-seq, a method that simultaneously measures surface and intracellular proteins and gene expression in single cells, validated in primary human T cells.

This study identifies cell-type-specific transcriptomic signatures associated with SLE disease establishment and exacerbation, highlighting their clinical relevance and potential limitations in capturing genetic risk factors.

This paper introduces ASAP-seq, a method to simultaneously profile chromatin accessibility, protein levels, and mtDNA in single cells, demonstrating its application in hematopoietic differentiation and T cell perturbations.