Sungwon Jeon

A Korean pangenome reference of 14 healthy individuals supports structural variant analysis in disease genomes

The paper constructs a Korean pangenome reference (K-PanRef) from 14 healthy individuals and demonstrates its utility in identifying disease-relevant structural variants in early-onset myocardial infarction samples.

GeroEngine: Generative single-cell aging trajectories reveal a bidirectionally traversable identity core and direction-specific inflammatory remodeling

GeroEngine reveals aging trajectories show bidirectional identity recovery and direction-specific inflammation, suggesting homeostatic restoration over inflammation suppression.

Telomere-to-telomere, accurate, and gapless genome assembly (TTAGGA) of the Korean Jindo dog with a single-contig Y chromosome

The paper presents a gapless, haplotype-resolved canine genome assembly for a Jindo dog, achieving high completeness and accuracy for the Y chromosome.

10,239 whole genomes with multiomic and clinical health information as the Korean Multiomics Reference dataset

The paper introduces Korea10K, a large genomic dataset of 10,239 Korean genomes with multiomic and clinical data, enabling population-specific variant imputation and insights into genomic-epigenomic regulation.

Identification of reactive CpGs and RNA expression in early COVID-19 through cis-eQTM analysis reflecting disease severity and recovery

The paper identifies reactive CpGs and RNA expression changes in early COVID-19 using eQTM analysis, showing reversible molecular shifts linked to disease severity and recovery.

Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation

The paper identifies 17 novel DNA methylation biomarkers for anxiety disorders through differential methylation analysis and validates them using machine learning models.

Fine-mapping SLE-MHC associations revealed independent contributions of HLA missense variants and C4 copy number variations

This study identifies independent genetic contributions of HLA missense variants and C4 copy number variations to SLE risk using a new East Asian MHC imputation panel.

Reversible Transcriptomic Age Shifts from Physiological Stress in Whole Blood

This study develops a transcriptomic clock to predict age from whole blood and shows that physiological stress like COVID-19 can induce reversible age acceleration.

Dokdo sea lion Zalophus japonicus genome reveals its evolutionary trajectory before extinction

The paper sequenced the genome of the extinct Dokdo sea lion to clarify its evolutionary history and genetic diversity before extinction.

A high-quality de novo genome assembly of Asian Crested Ibis (Nipponia Nippon) using long-read and Hi-C data

The paper presents a high-quality de novo genome assembly of the Asian Crested Ibis using long-read and Hi-C data, achieving a higher N50 and gene completeness compared to previous assemblies.

Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups

Korea4K presents whole-genome sequences of 4,157 Koreans with 107 health parameters, identifying new genotype-phenotype associations and improving imputation performance.

Genome-wide analyses of early-onset acute myocardial infarction identify 29 novel loci by whole genome sequencing

This study identifies 29 novel genetic loci associated with early-onset acute myocardial infarction through whole-genome sequencing of 1,239 Koreans.

The Lithuanian reference genome LT1 - a human de novo genome assembly with short and long read sequence and Hi-C data

The paper presents LT1, a high-quality human reference genome assembled using long-read and Hi-C data, and reports its genomic features and availability as a public resource.

Comparative analysis of seven short-reads sequencing platforms using the Korean Reference Genome: MGI and Illumina sequencing benchmark for whole-genome sequencing

The paper compares seven short-read sequencing platforms using the Korean Reference Genome, finding MGI platforms match Illumina in quality and cost-effectiveness.

Complete genome sequence and analysis of nine Egyptian females with clinical information from different geographic regions in Egypt

The paper reports whole-genome sequences of nine Egyptian females with clinical data, identifying SNPs and mtDNA mutations associated with obesity and CPEO, and analyzing genetic admixture patterns.

The whale shark genome reveals how genomic and physiological properties scale with body size

The paper analyzes the whale shark genome to identify genetic features correlated with body size, metabolic rate, and lifespan, finding unique genomic traits in this species.

Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping information

This study compares the cost-effectiveness and quality of chromosome-scale genome assemblies using PromethION and PacBio sequencing for the Korean reference genome KOREF, finding PromethION to be more cost-effective with comparable or better quality.

The jellyfish genome sheds light on the early evolution of active predation

The paper analyzes the genome and transcriptomes of jellyfish to identify genetic adaptations related to active predation and body plan development.

The draft genome of an octocoral, Dendronephthya gigantea

This paper presents the first genome assembly of the non-symbiotic octocoral Dendronephthya gigantea to aid in comparative genomic studies of cnidarians and explore genetic differences between soft and stony corals.

Myotis rufoniger Genome Sequence and Analyses: M. rufoniger’s Genomic Feature and the Decreasing Effective Population Size of Myotis Bats

The genetics of an early Neolithic pastoralist from the Zagros, Iran

This study sequences and analyzes the first genome of an early Neolithic woman from Iran, showing her population was genetically distinct from Neolithic Anatolians and had limited genetic contribution to modern Europeans.