PDL-1+ Neutrophils mediate susceptibility during endotoxemia in Metabolic Dysfunction Associated Steatotic Liver Disease
Cleyson da Cruz Oliveira Barros, Alexandre Kanashiro, Gabriel Victor Lucena da Silva, Paulo Sérgio de Almeida Augusto, Guilherme Cesar Martelossi Cebinelli, Luiz Osório Leiria, Thiago M. Cunha, José Carlos Farias Alves Filho, Fernando Q. Cunha
This study identifies PD-L1+ neutrophils as mediators of susceptibility to endotoxemia in MAFLD, showing that targeting IFN-γ or PD-L1 reduces inflammation and liver damage.
bioRxiv · Oct 16, 2024 · PreprintImmunology