Author

James Lee

Howard Hughes Medical InstituteORCID 0000-0002-8551-0258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Jue CheniD· 2 shared Victor A. ManoniD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBiophysics

Jue ChenORCID

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2 papers

Recent·Most cited

BiophysicsImmunityPeer-reviewedAug 29, 2025

Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing

James Lee, Victor A. Manon, Jue Chen

This study reports cryo-EM structures of TAP in multiple functional states, revealing how nucleotide-dependent conformational changes drive peptide transport and release.

3 citations

humancryo-EM

𝕏 PostBluesky

BiophysicsbioRxivPreprintJun 19, 2025

A Structural Atlas of TAP Inhibition by Herpesviruses and Poxviruses

James Lee, Victor A. Manon, Jue Chen

This study reports cryo-EM structures of TAP inhibited by four viral proteins, revealing a common mechanism to block antigen presentation.

2 citations

cryo-EMexperimental assay

𝕏 PostBluesky