Victor A. Manon

This study reports cryo-EM structures of TAP in multiple functional states, revealing how nucleotide-dependent conformational changes drive peptide transport and release.

This study reports cryo-EM structures of TAP inhibited by four viral proteins, revealing a common mechanism to block antigen presentation.

The paper identifies amino acids critical for tau strain propagation by analyzing their role in amyloid templating across different tauopathies.

The paper identifies specific glycosaminoglycan (GAG) structural requirements for the uptake of Tau, Aβ, and α-synuclein aggregates by cells.