Simone M. Cacciò

The paper identifies an introgressed galectin-like protein in Cryptosporidium parvum anthroponosum as a potential driver of its human tropism through interaction with the human insulin-degrading enzyme.

Parapipe is a bioinformatics pipeline for analyzing Cryptosporidium NGS data, enabling variant calling, MOI analysis, and phylogenomic clustering to improve public health surveillance.

The paper uses whole genome sequencing to identify three distinct populations of Cryptosporidium parvum, showing the emergence and spread of a European population to the USA.

VIVID is a web tool that visualizes and interprets DNA variants in 3D on protein models to study genetic variation and its association with phenotypes.

The paper analyzes global population genomics of two C. hominis subspecies over 500 years, identifying divergence, transmission patterns, and introgression between them.

The paper describes an informatics platform for structured data storage and pre-publication sharing of pathogen sequencing data with stakeholders.