Aaron R. Jex

An introgressed galectin-like protein is a candidate driver of the human tropism in the intestinal parasite Cryptosporidium

The paper identifies an introgressed galectin-like protein in Cryptosporidium parvum anthroponosum as a potential driver of its human tropism through interaction with the human insulin-degrading enzyme.

Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling.

The paper shows iron deficiency reduces Plasmodium parasitemia in pregnant women and mice, and iron supplementation does not increase parasitemia when combined with malaria prevention.

Machine learning driven image segmentation and shape clustering of algal microscopic images obtained from various water types

This study applies FastSAM for automated algal cell segmentation and clustering in water samples, showing high accuracy for single cells and varying clustering performance.

VIVID: a web application for variant interpretation and visualisation in multidimensional analyses

VIVID is a web tool that visualizes and interprets DNA variants in 3D on protein models to study genetic variation and its association with phenotypes.

Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures

This study uses single-cell RNA sequencing to analyze P. vivax sporozoites, identifying stage-specific transcriptomic signatures and gene usage patterns distinct from P. falciparum.

Global population genomics of two subspecies of Cryptosporidium hominis during 500 years of evolution

The paper analyzes global population genomics of two C. hominis subspecies over 500 years, identifying divergence, transmission patterns, and introgression between them.

Precise gene models using long-read sequencing reveal a unique poly(A) signal in Giardia lamblia

The paper uses long-read sequencing to analyze poly(A) signals in Giardia lamblia, revealing a unique AGURAA signal and alternative polyadenylation events.

Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal new biological insights

The paper presents a new high-quality genome assembly and annotation for Cryptosporidium parvum IOWA, revealing structural and functional insights into its genome and evolutionary relationships with related species.

Direct nanopore sequencing of mRNA reveals landscape of transcript isoforms in apicomplexan parasites

This study uses direct nanopore sequencing to analyze alternative splicing in apicomplexan parasites, finding widespread intron retention and premature stop codons, suggesting alternative splicing contributes to transcriptomic diversity.

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation.

This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.