MicrobiologybioRxivPreprint
Epithelial innate immune sensing of pneumococci is inherently restricted to a small cellular minority across species and infection niches
Vikrant Minhas, Vincent de Bakker, Kin Ki Jim…·Jan‐Willem Veening
The paper shows pneumococcal infection activates innate immune genes in only 1-4% of lung epithelial cells, contrasting with E. coli's 40% response, and identifies prostaglandin signaling as protective during invasive disease.