Kin Ki Jim

The paper shows pneumococcal infection activates innate immune genes in only 1-4% of lung epithelial cells, contrasting with E. coli's 40% response, and identifies prostaglandin signaling as protective during invasive disease.

This paper identifies the pneumococcal S protein as essential for resisting host antimicrobials by coordinating cell wall modification and repair through interactions with PBP1a and PgdA.

This study uses in vivo CRISPRi-Seq in zebrafish to identify host-adaptive pathways essential for pneumococcal meningitis and discover new therapeutic targets.

The paper identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae using CRISPRi-seq and antibiotic combination therapy.

This paper introduces a transgenic zebrafish model expressing claudin 5a to study the development and function of the blood-brain barrier and choroid plexus barrier in vivo.