Xenia Kostoulias

Developing a sensitive indoor air surveillance approach for nosocomial pathogens and antimicrobial resistance

This study evaluates a high-volume air sampling approach to detect bioaerosols in indoor environments, showing its sensitivity and association with human activity and AMR transmission risks.

Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice

This study identifies genes essential for two P. multocida strains to survive in mice, revealing differential requirements for systemic infection despite shared growth genes.

Rational Design of Frontline Institutional Phage Cocktail for the Treatment of Nosocomial Enterobacter cloacae Complex Infections

The paper develops a phage cocktail, Entelli-02, effective against multidrug-resistant Enterobacter cloacae complex strains with 99% coverage and 92% efficacy in a hospital strain collection.

Bacterial species and surface structures shape gene transfer and the transcriptional landscape during active conjugation

The paper shows active conjugation triggers host transcriptional changes, which are blocked by capsule expression but overcome by plasmid-driven single-cell variation.

Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection

This study tracks the evolution of carbapenem resistance in Acinetobacter baumannii during a 45-day infection in a burn patient, identifying novel mutations in resistance genes and showing collateral resistance from exposure to other antibiotics.