Author

Nenad Maćešić

The Alfred HospitalORCID 0000-0002-7905-628XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:graph neural network· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Anton Yariv PelegiD· 3 shared Jessica A. WisniewskiiD· 2 shared Luke V. BlakewayiD· 2 shared Anna G. GreeniD· 1 shared Avindya Perera· 1 shared Ben VezinaiD· 1 shared David L. DoweiD· 1 shared Denis KorneeviD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMicrobiology

Anton Yariv PelegORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

AMR-GNN: A multi-representation graph neural network framework to enable genomic antimicrobial resistance prediction

Hoai-An Nguyen, Anton Y. Peleg, Jessica A. Wisniewski, Xiaoyu Wang, Zhikang Wang, Luke V. Blakeway, Gnei Z. Badoordeen, Ravali Theegala, Nhu Quynh Doan, Matthew H. Parker, Anna G. Green, Jiangning Song, David L. Dowe, Nenad Maćešić

AMR-GNN predicts antimicrobial resistance using a graph neural network framework that integrates multiple genomic representations from whole-genome sequencing data.

Nature Communications · Mar 6, 2026Peer-reviewedGenomics

Rational Design of Frontline Institutional Phage Cocktail for the Treatment of Nosocomial Enterobacter cloacae Complex Infections

Dinesh Subedi, Fernando L. Gordillo Altamirano, Rylee Deehan, Avindya Perera, Ruzeen Rohintan Patwa, Xenia Kostoulias, Denis Korneev, Luke V. Blakeway, Nenad Maćešić, Anton Yariv Peleg, Jeremy J. Barr

The paper develops a phage cocktail, Entelli-02, effective against multidrug-resistant Enterobacter cloacae complex strains with 99% coverage and 92% efficacy in a hospital strain collection.

Nature Microbiology · Sep 24, 2025Peer-reviewedMicrobiology

Targeted sequencing of Enterobacterales bacteria using CRISPR-Cas9 enrichment and Oxford Nanopore Technologies

Hugh Cottingham, Louise M. Judd, Jessica A. Wisniewski, Ryan R. Wick, Thomas D. Stanton, Ben Vezina, Nenad Maćešić, Anton Yariv Peleg, Iruka N. Okeke, Kathryn E. Holt, Jane Hawkey

This paper demonstrates that CRISPR-Cas9 enrichment combined with Oxford Nanopore sequencing improves detection of AMR genes and MLST in patient samples compared to unenriched sequencing.

mSystems · Jan 8, 2025Peer-reviewedMicrobiology