Anton Yariv Peleg

Disruption of cAMP Signalling and RNA Regulation Confers Cefiderocol Resistance in Acinetobacter baumannii

This study identifies two mechanisms of cefiderocol resistance in Acinetobacter baumannii: cAMP signalling disruption and Hfq RNA-binding domain truncation, both linked to iron homeostasis and reduced drug activity.

Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure

The paper identifies pre-existing anti-prophage antibodies and bacterial heteroresistance as factors contributing to phage therapy failure in a patient with chronic infection.

AMR-GNN: A multi-representation graph neural network framework to enable genomic antimicrobial resistance prediction

AMR-GNN predicts antimicrobial resistance using a graph neural network framework that integrates multiple genomic representations from whole-genome sequencing data.

Rational Design of Frontline Institutional Phage Cocktail for the Treatment of Nosocomial Enterobacter cloacae Complex Infections

The paper develops a phage cocktail, Entelli-02, effective against multidrug-resistant Enterobacter cloacae complex strains with 99% coverage and 92% efficacy in a hospital strain collection.

Targeted sequencing of Enterobacterales bacteria using CRISPR-Cas9 enrichment and Oxford Nanopore Technologies

This paper demonstrates that CRISPR-Cas9 enrichment combined with Oxford Nanopore sequencing improves detection of AMR genes and MLST in patient samples compared to unenriched sequencing.

genomicBERT: A Light-weight Foundation Model for Genome Analysis using Unigram Tokenization and Specialized DNA Vocabulary

This paper introduces genomicBERT, a lightweight genome analysis model that improves efficiency and performance through specialized DNA vocabulary and tokenization, validated across diverse case studies.

Comprehensive antibiotic-linked mutation assessment by Resistance Mutation Sequencing (RM-seq)

RM-seq detects and quantifies antibiotic resistance mutations in bacterial populations with high sensitivity and accuracy.

Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection

This study tracks the evolution of carbapenem resistance in Acinetobacter baumannii during a 45-day infection in a burn patient, identifying novel mutations in resistance genes and showing collateral resistance from exposure to other antibiotics.