Ashok Sekhar

Morpheus-3D: Structural Diversity-Guided Detection and Localization of Protein Fold Switching

Morpheus-3D detects and localizes fold-switching proteins using sequence-based entropy profiles, outperforming existing methods and revealing widespread structural plasticity across proteomes.

Structure of a sparsely populated chimeric intermediate that facilitates fold-switching of a metamorphic protein

The paper visualizes an invisible chimeric intermediate in the fold-switching pathway of a metamorphic protein using NMR techniques and shows its role as an on-pathway intermediate.

Tannic acid fortifies extracellular matrix against dicarbonyl stress

This study shows tannic acid protects extracellular matrix from methylglyoxal-induced damage by stabilizing its biochemical properties and restoring cell adhesion.

Morpheus: A fragment-based algorithm to predict metamorphic behaviour in proteins across proteomes

Morpheus predicts fold-switching proteins by analyzing structural fragments across proteomes, identifying 10% of proteins with metamorphic behavior.