Martin J. Kelly

This study identifies STX, a non-steroidal estrogenic compound, as targeting mitochondrial VDAC2 to enhance bioenergetics and provide neuroprotection in hypothalamic POMC neurons.

The paper identifies arcuate nucleus Kiss1 neurons as regulators of energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus in male mice.

The paper shows estradiol changes ion channel activity in kisspeptin neurons, altering their firing patterns and affecting GnRH release through glutamatergic signaling.

This study shows that MC4R in Kiss1 neurons regulates female fertility by modulating GnRH pulse generation and preovulatory LH surge through distinct signaling mechanisms.

This study shows that deleting Stim1 in Kiss1 neurons increases their excitability and protects against diet-induced obesity.

This study uses CRISPR to knock down Kcnq3 in NPY/AgRP neurons, reducing the M-current and increasing neuronal excitability without affecting ingestive behavior but decreasing locomotor activity.